Structure of the bifunctional isocitrate dehydrogenase kinase/phosphatase

Jimin Zheng and Zongchao Jia ()
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Jimin Zheng: Queen’s University, Kingston, Ontario K7L 3N6, Canada
Zongchao Jia: Queen’s University, Kingston, Ontario K7L 3N6, Canada

Nature, 2010, vol. 465, issue 7300, 961-965

Abstract: Structure of a kinase/phosphatase The Escherichia coli isocitrate dehydrogenase kinase/phosphatase (AceK) is a bifunctional enzyme that phosphorylates/dephosphorylates isocitrate dehydrogenase (ICDH) to either inactivate/activate the enzyme in response to environmental changes. In this paper, the authors solve the structures of AceK and the AceK/ICDH co-complex, revealing the conformational changes that occur when this enzyme changes from a kinase to a phosphatase and vice versa.

Date: 2010
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DOI: 10.1038/nature09088

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