Presynaptic activity regulates Na+ channel distribution at the axon initial segment

Hiroshi Kuba (), Yuki Oichi and Harunori Ohmori
Additional contact information
Hiroshi Kuba: Career-Path Promotion Unit for Young Life Scientists,
Yuki Oichi: Career-Path Promotion Unit for Young Life Scientists,
Harunori Ohmori: Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan

Nature, 2010, vol. 465, issue 7301, 1075-1078

Abstract: A centre for neural control The axon initial segment (AIS) at the base of each nerve fibre, where clusters of sodium channels generate the action potential that then propagates along the axon, is a focus of much attention from neuroscientists working on the nature of neuronal excitability. As the source of a nerve impulse, it seems a logical point at which to regulate neural activity. Two papers in this issue confirm that the AIS is a source of intrinsic neuronal plasticity. Matthew Grubb and Juan Burrone show that electrical activity reversibly alters the position of the AIS in cultured hippocampal neurons. They suggest that the resulting increase in intrinsic excitability may fine-tune neuronal excitability during development, and point to potential targets for the control of epilepsy. Hiroshi Kuba, Yuki Oichi and Harunori Ohmori show that the size of the AIS increases in bird auditory neurons deprived of sound stimulation. Again intrinsic excitability increases, possibly contributing to the maintenance of the auditory pathway. Such neuronal plasticity may compensate some forms of hearing loss.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature09087 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:465:y:2010:i:7301:d:10.1038_nature09087

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09087

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().