Human adult germline stem cells in question

Kinarm Ko, Marcos J. Araúzo-Bravo, Natalia Tapia, Julee Kim, Qiong Lin, Christof Bernemann, Dong Wook Han, Luca Gentile, Peter Reinhardt, Boris Greber, Rebekka K. Schneider, Sabine Kliesch, Martin Zenke and Hans R. Schöler ()
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Kinarm Ko: Max Planck Institute for Molecular Biomedicine
Marcos J. Araúzo-Bravo: Max Planck Institute for Molecular Biomedicine
Natalia Tapia: Max Planck Institute for Molecular Biomedicine
Julee Kim: Max Planck Institute for Molecular Biomedicine
Qiong Lin: Institute for Biomedical Engineering, RWTH Aachen University Medical School
Christof Bernemann: Max Planck Institute for Molecular Biomedicine
Dong Wook Han: Max Planck Institute for Molecular Biomedicine
Luca Gentile: Max Planck Institute for Molecular Biomedicine
Peter Reinhardt: Max Planck Institute for Molecular Biomedicine
Boris Greber: Max Planck Institute for Molecular Biomedicine
Rebekka K. Schneider: Institute for Biomedical Engineering, RWTH Aachen University Medical School
Sabine Kliesch: Centre for Reproductive Medicine and Andrology, University of Münster
Martin Zenke: Institute for Biomedical Engineering, RWTH Aachen University Medical School
Hans R. Schöler: Max Planck Institute for Molecular Biomedicine

Nature, 2010, vol. 465, issue 7301, E1-E1

Abstract: Abstract Arising from: S. Conrad et al. Nature 456, 344–349 (2008)10.1038/nature07404 ; Conrad et al. reply Conrad et al. have generated human adult germline stem cells (haGSCs) from human testicular tissue, which they claim have similar pluripotent properties to human embryonic stem cells (hESCs)1. Here we investigate the pluripotency of haGSCs by using global gene-expression analysis based on their gene array data1 and comparing the expression of pluripotency marker genes in haGSCs and hESCs, and in haGSCs and human fibroblast samples derived from different laboratories, including our own. We find that haGSCs and fibroblasts have a similar gene-expression profile, but that haGSCs and hESCs do not. The pluripotency of Conrad and colleagues’ haGSCs is therefore called into question.

Date: 2010
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DOI: 10.1038/nature09089

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