Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription

Shouhong Guang, Aaron F. Bochner, Kirk B. Burkhart, Nick Burton, Derek M. Pavelec and Scott Kennedy ()
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Shouhong Guang: Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
Aaron F. Bochner: Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
Kirk B. Burkhart: Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
Nick Burton: Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA
Derek M. Pavelec: University of Wisconsin, Madison, Wisconsin 53706, USA
Scott Kennedy: Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA

Nature, 2010, vol. 465, issue 7301, 1097-1101

Abstract: NRDE-2 active in transcription regulation Small RNAs function in both the cytoplasm, inhibiting expression from messenger RNAs, and in the nucleus, to silence heterochromatin and prevent genome rearrangement. In this study, Guang et al. characterize a new protein involved in RNA interference in the nucleus. NRDE-2 associates with the Argonaute protein NRDE-3 and siRNAs on nascent transcripts. This association prevents elongation by RNA polymerase II, thereby making this a co-transcriptional form of gene silencing.

Date: 2010
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DOI: 10.1038/nature09095

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