Activation of autophagy during cell death requires the engulfment receptor Draper

Christina K. McPhee, Mary A. Logan, Marc R. Freeman and Eric H. Baehrecke ()
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Christina K. McPhee: University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Mary A. Logan: University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Marc R. Freeman: University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Eric H. Baehrecke: University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA

Nature, 2010, vol. 465, issue 7301, 1093-1096

Abstract: Draper protein regulates autophagy during cell death Autophagy, the process by which a cell digests its own components in the lysosomes, is an ancient and well-conserved pathway that acts as a survival response to starvation but has also been associated with cell death. In this study, McPhee et al. identify the first factor that regulates autophagy during cell death, but not during cell survival. They find that in Drosophila, the engulfment receptor Draper is a critical regulator of autophagy during cell death of Drosophila salivary glands but is not required for starvation-induced autophagy during fat body cell survival. This is the first example of an engulfment factor that is autonomously required for self-clearance.

Date: 2010
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DOI: 10.1038/nature09127

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