The male mouse pheromone ESP1 enhances female sexual receptive behaviour through a specific vomeronasal receptor

Sachiko Haga, Tatsuya Hattori, Toru Sato, Koji Sato, Soichiro Matsuda, Reiko Kobayakawa, Hitoshi Sakano, Yoshihiro Yoshihara, Takefumi Kikusui and Kazushige Touhara ()
Additional contact information
Sachiko Haga: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Tatsuya Hattori: Companion Animal Research, School of Veterinary Medicine, Azabu University
Toru Sato: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Koji Sato: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Soichiro Matsuda: Graduate School of Agricultural and Life Sciences, The University of Tokyo
Reiko Kobayakawa: Osaka Bioscience Institute
Hitoshi Sakano: Graduate School of Science, The University of Tokyo
Yoshihiro Yoshihara: Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute
Takefumi Kikusui: Companion Animal Research, School of Veterinary Medicine, Azabu University
Kazushige Touhara: Graduate School of Agricultural and Life Sciences, The University of Tokyo

Nature, 2010, vol. 466, issue 7302, 118-122

Abstract: Driven to tears Pheromones and their detection by the vomeronasal organ are known to govern social behaviour in mice, but few chemical signals have been linked to specific behavioural responses. Haga et al. now show that the ESP1 peptide secreted in male tears makes females sexually receptive, and have identified its specific vomeronasal receptor (V2Rp5) and the sex-specific neuronal circuits activated during the behavioural response. Whether such 'labelled line' logic extends to the regulation of reproductive behaviour in other mammals remains unclear.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature09142 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:466:y:2010:i:7302:d:10.1038_nature09142

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09142

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().