Structural basis for the coupling between activation and inactivation gates in K+ channels

Luis G. Cuello, Vishwanath Jogini, D. Marien Cortes, Albert C. Pan, Dominique G. Gagnon, Olivier Dalmas, Julio F. Cordero-Morales, Sudha Chakrapani, Benoît Roux and Eduardo Perozo ()
Additional contact information
Luis G. Cuello: The University of Chicago
Vishwanath Jogini: The University of Chicago
D. Marien Cortes: The University of Chicago
Albert C. Pan: The University of Chicago
Dominique G. Gagnon: The University of Chicago
Olivier Dalmas: The University of Chicago
Julio F. Cordero-Morales: The University of Chicago
Sudha Chakrapani: The University of Chicago
Benoît Roux: The University of Chicago
Eduardo Perozo: The University of Chicago

Nature, 2010, vol. 466, issue 7303, 272-275

Abstract: Potassium channels: the active-to-inactive switch Switching between conductive and non-conductive states is central to the function of ion channels. In potassium channels, inactivation gating occurs by two distinct molecular mechanisms: N-type inactivation (a rapid autoinhibitory process in which an N-terminal particle blocks conduction by binding to the open pore) and C-type inactivation (originating from conformational transitions at the selectivity filter). In the first of two papers, Eduardo Perozo and co-workers solve the X-ray crystal structure of the K+ channel KcsA in an 'open-inactivated' conformation together with a series of crystal structures of channels that are 'trapped' in a set of partially open conformations. In the second paper, the authors identify the underlying mechanism by which movements in the inner gate of this channel trigger conformational changes at the selectivity filter, leading to the non-conductive C-type inactivated state.

Date: 2010
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DOI: 10.1038/nature09136

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