Loss of fish actinotrichia proteins and the fin-to-limb transition

Jing Zhang, Purva Wagh, Danielle Guay, Luis Sanchez-Pulido, Bhaja K. Padhi, Vladimir Korzh, Miguel A. Andrade-Navarro and Marie-Andrée Akimenko ()
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Jing Zhang: CAREG, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
Purva Wagh: CAREG, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
Danielle Guay: CAREG, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada
Luis Sanchez-Pulido: Functional Genomics Unit, Anatomy and Genetics, University of Oxford
Bhaja K. Padhi: Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario K1A 0L2, Canada
Vladimir Korzh: Institute of Molecular and Cell Biology
Miguel A. Andrade-Navarro: Max Delbrück Center for Molecular Medicine
Marie-Andrée Akimenko: CAREG, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada

Nature, 2010, vol. 466, issue 7303, 234-237

Abstract: The fin-to-limb transition A significant step in the evolution of tetrapod limbs was the loss of the distinctive fringe of fin-rays and fin-folds found in the fins of fishes. Marie-Andrée Akimenko and colleagues have identified two novel zebrafish proteins, actinodin 1 and 2, as essential structural components of these features. Actinodin genes are found in other fish species — including several teleost fishes and in the elephant shark — but are not present in tetrapods. The experimental loss of actinodin function leads to the absence of actinotrichia fibrils in zebrafish and to the formation of pectoral fin buds with characteristics of tetrapod limb buds. The data suggest that the loss of actinotrichia fibrils may, in part, explain the evolutionary transformation of fins into limbs.

Date: 2010
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DOI: 10.1038/nature09137

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