Single-cell NF-κB dynamics reveal digital activation and analogue information processing

Savaş Tay, Jacob J. Hughey, Timothy K. Lee, Tomasz Lipniacki (), Stephen R. Quake () and Markus W. Covert ()
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Savaş Tay: Stanford University, Stanford, California 94305, USA
Jacob J. Hughey: Stanford University, Stanford, California 94305, USA
Timothy K. Lee: Stanford University, Stanford, California 94305, USA
Tomasz Lipniacki: Institute of Fundamental Technological Research
Stephen R. Quake: Stanford University, Stanford, California 94305, USA
Markus W. Covert: Stanford University, Stanford, California 94305, USA

Nature, 2010, vol. 466, issue 7303, 267-271

Abstract: Single-cell information processing Multicellular organisms, particularly their immune systems, rely on complex cell-to-cell communications, the molecular mechanisms of which have been studied largely qualitatively, based on data averaged over heterogeneous cell populations. Now, Tay et al. have used high-throughput microfluidics to quantitatively measure the response of genes controlled by the DNA-binding protein NF-κB, in response to a wide (10,000-fold) range of doses of the cell–cell signalling molecule TNF-α, at the single-cell level in thousands of live cells. The results reveal all-or-none (digital) decisions of single cells at low levels of signalling, and graded (analogue) responses above.

Date: 2010
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DOI: 10.1038/nature09145

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