A random cell motility gradient downstream of FGF controls elongation of an amniote embryo

Bertrand Bénazéraf, Paul Francois, Ruth E. Baker, Nicolas Denans, Charles D. Little and Olivier Pourquié ()
Additional contact information
Bertrand Bénazéraf: Howard Hughes Medical Institute
Paul Francois: Center for Studies in Physics and Biology, The Rockefeller University
Ruth E. Baker: Centre for Mathematical Biology, Mathematical Institute, University of Oxford
Nicolas Denans: Stowers Institute for Medical Research
Charles D. Little: University of Kansas Medical Center
Olivier Pourquié: Howard Hughes Medical Institute

Nature, 2010, vol. 466, issue 7303, 248-252

Abstract: Controlling embryonic growth Most animal embryos grow through cell accumulation in a posterior growth zone, but the morphogenic forces that control the formation and directionality of the growth are unknown. Based on a study of axis elongation during formation of the trunk and tail structures in the chicken embryo, Bénazéraf et al. propose that tissue elongation in response to signalling mediated by fibroblast growth factor is a property emerging from the collective regulation of graded, random cell motion rather than by the regulation of directionality of individual cellular movements.

Date: 2010
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DOI: 10.1038/nature09151

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