Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning

Hai Song, Jianxin Hu, Wen Chen, Gene Elliott, Philipp Andre, Bo Gao and Yingzi Yang ()
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Hai Song: Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
Jianxin Hu: Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
Wen Chen: Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
Gene Elliott: Transgenic Mouse Core, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
Philipp Andre: Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
Bo Gao: Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
Yingzi Yang: Developmental Genetics Section, Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA

Nature, 2010, vol. 466, issue 7304, 378-382

Abstract: Body line decisions The three animal body axes are established sequentially during development — first the anteroposterior and dorsoventral axes, and then left–right asymmetry — but how the latter derives from the former has been unclear. Now, Yingzi Yang and colleagues show that two mouse genes belonging to the 'planar cell polarity' family (Vangl1 and Vangl2) are required for the posterior deposition of cilia, which in turn determines the leftward nodal flow across the posterior notochord. This work suggests that planar cell polarity is an evolutionarily conserved mechanism that transmits the predetermined anteroposterior positional information and converts it to the first lateral symmetry-breaking event in the embryo.

Date: 2010
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DOI: 10.1038/nature09129

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