Relationship between nucleosome positioning and DNA methylation

Ramakrishna K. Chodavarapu, Suhua Feng, Yana V. Bernatavichute, Pao-Yang Chen, Hume Stroud, Yanchun Yu, Jonathan A. Hetzel, Frank Kuo, Jin Kim, Shawn J. Cokus, David Casero, Maria Bernal, Peter Huijser, Amander T. Clark, Ute Krämer, Sabeeha S. Merchant, Xiaoyu Zhang, Steven E. Jacobsen () and Matteo Pellegrini ()
Additional contact information
Ramakrishna K. Chodavarapu: Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
Suhua Feng: Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
Yana V. Bernatavichute: Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
Pao-Yang Chen: Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
Hume Stroud: Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
Yanchun Yu: University of Georgia, Athens, Georgia 30602, USA
Jonathan A. Hetzel: Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
Frank Kuo: Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
Jin Kim: Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
Shawn J. Cokus: Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
David Casero: Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
Maria Bernal: University of Heidelberg, BIOQUANT 23, R. 645, Im Neuenheimer Feld 267, D-69120 Heidelberg, Germany
Peter Huijser: Max Planck Institute for Plant Breeding Research
Amander T. Clark: Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
Ute Krämer: University of Heidelberg, BIOQUANT 23, R. 645, Im Neuenheimer Feld 267, D-69120 Heidelberg, Germany
Sabeeha S. Merchant: Molecular Biology Institute, University of California Los Angeles, Los Angeles, California 90095, USA
Xiaoyu Zhang: University of Georgia, Athens, Georgia 30602, USA
Steven E. Jacobsen: Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
Matteo Pellegrini: Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA

Nature, 2010, vol. 466, issue 7304, 388-392

Abstract: Plant nucleosome positioning A genome-wide analysis in the plant Arabidopsis thaliana of the positioning of the nucleosomes — the nucleoprotein molecules that organize and control access to genomic DNA — combined with profiles of DNA methylation at single-base resolution, reveals 10-base periodicities in the DNA methylation status of nucleosome-bound DNA. The results suggest that nucleosome position influences DNA methylation patterning in the genome, and that DNA methyltransferases preferentially target nucleosome-bound DNA. Similar trends were observed in human nucleosomal DNA, indicating that the relationships between nucleosomes and DNA methyltransferases are conserved.

Date: 2010
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DOI: 10.1038/nature09147

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