Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel

Yunkun Wu, Yi Yang, Sheng Ye and Youxing Jiang ()
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Yunkun Wu: University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, USA
Yi Yang: University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, USA
Sheng Ye: Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China
Youxing Jiang: University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, USA

Nature, 2010, vol. 466, issue 7304, 393-397

Abstract: Gating ring structure High-conductance Ca2+-gated K+ (BK) channels are essential for many biological processes such as smooth muscle contraction and neurotransmitter release. In this study, Yunkun Wu et al. report the X-ray crystal structure of the entire intracellular cytoplasmic region of the human BK channel in a Ca2+-free state. The authors 'docked' a voltage-gated K+ channel pore of known structure onto the gating ring to generate a structural model for the full BK channel.

Date: 2010
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DOI: 10.1038/nature09252

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