Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry

Alexxai V. Kravitz, Benjamin S. Freeze, Philip R. L. Parker, Kenneth Kay, Myo T. Thwin, Karl Deisseroth and Anatol C. Kreitzer ()
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Alexxai V. Kravitz: Gladstone Institute of Neurological Disease
Benjamin S. Freeze: Gladstone Institute of Neurological Disease
Philip R. L. Parker: Gladstone Institute of Neurological Disease
Kenneth Kay: Gladstone Institute of Neurological Disease
Myo T. Thwin: Gladstone Institute of Neurological Disease
Karl Deisseroth: Stanford University
Anatol C. Kreitzer: Gladstone Institute of Neurological Disease

Nature, 2010, vol. 466, issue 7306, 622-626

Abstract: Control of parkinsonian behaviour The basal ganglia are a collection of interconnected brain areas thought to be crucial for motor planning, sequencing and execution. It has long been thought that motor control is achieved through the balanced activity of two parallel and anatomically distinct pathways, acting on the basal ganglia with opposing effects, but these pathways have never been functionally verified. Kravitz et al. have tested this hypothesis directly using optogenetic activation of different populations of mouse striatal neurons, and they both trace functional connectivity and demonstrate opposing effects on motor behaviour. Selective activation of the 'direct' pathway increased locomotion and rescued motor deficits in a parkinsonian model, whereas activation of the 'indirect' pathway suppressed motor behaviour.

Date: 2010
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DOI: 10.1038/nature09159

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