Cross-species genomics matches driver mutations and cell compartments to model ependymoma

Robert A. Johnson, Karen D. Wright, Helen Poppleton, Kumarasamypet M. Mohankumar, David Finkelstein, Stanley B. Pounds, Vikki Rand, Sarah E. S. Leary, Elsie White, Christopher Eden, Twala Hogg, Paul Northcott, Stephen Mack, Geoffrey Neale, Yong-Dong Wang, Beth Coyle, Jennifer Atkinson, Mariko DeWire, Tanya A. Kranenburg, Yancey Gillespie, Jeffrey C. Allen, Thomas Merchant, Fredrick A. Boop, Robert. A. Sanford, Amar Gajjar, David W. Ellison, Michael D. Taylor, Richard G. Grundy and Richard J. Gilbertson ()
Additional contact information
Robert A. Johnson: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Karen D. Wright: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Helen Poppleton: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Kumarasamypet M. Mohankumar: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
David Finkelstein: Hartwell Centre for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Stanley B. Pounds: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Vikki Rand: Northern Institute for Cancer Research, University of Newcastle upon Tyne
Sarah E. S. Leary: Hematology-Oncology, Seattle Children's Hospital
Elsie White: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Christopher Eden: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Twala Hogg: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Paul Northcott: Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M4N 1X8, Canada
Stephen Mack: Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M4N 1X8, Canada
Geoffrey Neale: Hartwell Centre for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Yong-Dong Wang: Hartwell Centre for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Beth Coyle: Children’s Brain Tumour Research Centre, University of Nottingham
Jennifer Atkinson: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Mariko DeWire: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Tanya A. Kranenburg: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Yancey Gillespie: University of Alabama
Jeffrey C. Allen: New York University, Langone Medical Center
Thomas Merchant: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Fredrick A. Boop: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Robert. A. Sanford: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Amar Gajjar: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
David W. Ellison: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
Michael D. Taylor: Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M4N 1X8, Canada
Richard G. Grundy: Children’s Brain Tumour Research Centre, University of Nottingham
Richard J. Gilbertson: St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA

Nature, 2010, vol. 466, issue 7306, 632-636

Abstract: Tumour diversity Ependymoma is a type of neural tumour that arises throughout the central nervous system. Using comparative transcriptomics in mouse and human tumours, Johnson et al. home in on mutations that are specific to individual tumour subgroups. In the course of their study, the authors generate the first mouse model of ependymoma and demonstrate the power of interspecific genomic comparisons to interrogate cancer subgroups.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (5)

Downloads: (external link)
https://www.nature.com/articles/nature09173 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:466:y:2010:i:7306:d:10.1038_nature09173

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09173

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().