New class of gene-termini-associated human RNAs suggests a novel RNA copying mechanism

Philipp Kapranov (), Fatih Ozsolak, Sang Woo Kim, Sylvain Foissac, Doron Lipson, Chris Hart, Steve Roels, Christelle Borel, Stylianos E. Antonarakis, A. Paula Monaghan, Bino John and Patrice M. Milos ()
Additional contact information
Philipp Kapranov: Helicos BioSciences Corporation, 1 Kendall Sq. Ste B7301 Cambridge, Massachusetts 02139-1671, USA
Fatih Ozsolak: Helicos BioSciences Corporation, 1 Kendall Sq. Ste B7301 Cambridge, Massachusetts 02139-1671, USA
Sang Woo Kim: University of Pittsburgh School of Medicine
Sylvain Foissac: Integromics, S.L., Grisolía 2, 28760 Tres Cantos, Madrid, Spain
Doron Lipson: Helicos BioSciences Corporation, 1 Kendall Sq. Ste B7301 Cambridge, Massachusetts 02139-1671, USA
Chris Hart: Helicos BioSciences Corporation, 1 Kendall Sq. Ste B7301 Cambridge, Massachusetts 02139-1671, USA
Steve Roels: Helicos BioSciences Corporation, 1 Kendall Sq. Ste B7301 Cambridge, Massachusetts 02139-1671, USA
Christelle Borel: University of Geneva Medical School, University of Geneva, 1 rue Michel-Servet, 1211 Geneva, Switzerland
Stylianos E. Antonarakis: University of Geneva Medical School, University of Geneva, 1 rue Michel-Servet, 1211 Geneva, Switzerland
A. Paula Monaghan: University of Pittsburgh
Bino John: University of Pittsburgh School of Medicine
Patrice M. Milos: Helicos BioSciences Corporation, 1 Kendall Sq. Ste B7301 Cambridge, Massachusetts 02139-1671, USA

Nature, 2010, vol. 466, issue 7306, 642-646

Abstract: Another clutch of small RNAs An analysis of short RNAs (with fewer than 200 nucleotides) from human cells using single molecule high-throughput sequencing has uncovered a previously unknown short RNA species with a difference. They all have the same 'tail' at their 5' ends, consisting of a sequence of non-genomically encoded polyU residues. This, together with the finding that these RNAs are closely associated with the 3' ends of known RNAs, points to the existence of a novel RNA-copying mechanism in human cells.

Date: 2010
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature09190 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:466:y:2010:i:7306:d:10.1038_nature09190

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09190

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().