Structure of the LexA–DNA complex and implications for SOS box measurement

Adrianna P. P. Zhang, Ying Z. Pigli and Phoebe A. Rice ()
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Adrianna P. P. Zhang: The University of Chicago
Ying Z. Pigli: The University of Chicago
Phoebe A. Rice: The University of Chicago

Nature, 2010, vol. 466, issue 7308, 883-886

Abstract: DNA repair: LexA–DNA structure Under normal conditions, expression of bacterial DNA damage-repair genes is repressed by the binding of LexA protein to 'SOS boxes' in their promoters. The presence of DNA damage activates the RecA strand-exchange protein, which promotes autocleavage of LexA such that its repression is relieved and repair proteins are expressed. Zhang et al. have now solved several structures of LexA dimer bound to SOS-box DNA, and find that the orientation of the DNA-binding wings can account for the strict inter-site spacing.

Date: 2010
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DOI: 10.1038/nature09200

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