Microtubule nucleating γ-TuSC assembles structures with 13-fold microtubule-like symmetry

Justin M. Kollman, Jessica K. Polka, Alex Zelter, Trisha N. Davis and David A. Agard ()
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Justin M. Kollman: Howard Hughes Medical Institute, and Keck Advanced Microscopy Center, University of California, San Francisco
Jessica K. Polka: Cellular and Molecular Pharmacology, University of California, San Francisco
Alex Zelter: University of Washington
Trisha N. Davis: University of Washington
David A. Agard: Howard Hughes Medical Institute, and Keck Advanced Microscopy Center, University of California, San Francisco

Nature, 2010, vol. 466, issue 7308, 879-882

Abstract: Microtubule symmetry Microtubules are an important component of the cytoskeleton, generally organized in vivo in groups of 13 protofilaments around a core of γ-tubulin complexes. How this precise geometry is controlled remains unclear. The structure of higher-order assemblies of the universally conserved core microtubule nucleating complex, γ-tubulin small complex (γTuSC) — isolated from the yeast Saccharomyces cerevisiae — has now been determined using cryo-electron microscopy. The structure provides insight into how γTuSC establishes thirteen-fold tubulin symmetry.

Date: 2010
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DOI: 10.1038/nature09207

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