Diverse somatic mutation patterns and pathway alterations in human cancers

Zhengyan Kan, Bijay S. Jaiswal, Jeremy Stinson, Vasantharajan Janakiraman, Deepali Bhatt, Howard M. Stern, Peng Yue, Peter M. Haverty, Richard Bourgon, Jianbiao Zheng, Martin Moorhead, Subhra Chaudhuri, Lynn P. Tomsho, Brock A. Peters, Kanan Pujara, Shaun Cordes, David P. Davis, Victoria E. H. Carlton, Wenlin Yuan, Li Li, Weiru Wang, Charles Eigenbrot, Joshua S. Kaminker, David A. Eberhard, Paul Waring, Stephan C. Schuster, Zora Modrusan, Zemin Zhang, David Stokoe, Frederic J. de Sauvage, Malek Faham and Somasekar Seshagiri ()
Additional contact information
Zhengyan Kan: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Bijay S. Jaiswal: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Jeremy Stinson: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Vasantharajan Janakiraman: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Deepali Bhatt: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Howard M. Stern: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Peng Yue: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Peter M. Haverty: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Richard Bourgon: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Jianbiao Zheng: Affymetrix Inc, 3420 Central Expressway, Santa Clara, California 95051, USA
Martin Moorhead: Affymetrix Inc, 3420 Central Expressway, Santa Clara, California 95051, USA
Subhra Chaudhuri: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Lynn P. Tomsho: Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab
Brock A. Peters: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Kanan Pujara: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Shaun Cordes: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
David P. Davis: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Victoria E. H. Carlton: Affymetrix Inc, 3420 Central Expressway, Santa Clara, California 95051, USA
Wenlin Yuan: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Li Li: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Weiru Wang: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Charles Eigenbrot: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Joshua S. Kaminker: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
David A. Eberhard: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Paul Waring: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Stephan C. Schuster: Pennsylvania State University, Center for Comparative Genomics and Bioinformatics, 310 Wartik Lab
Zora Modrusan: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Zemin Zhang: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
David Stokoe: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Frederic J. de Sauvage: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Malek Faham: Affymetrix Inc, 3420 Central Expressway, Santa Clara, California 95051, USA
Somasekar Seshagiri: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA

Nature, 2010, vol. 466, issue 7308, 869-873

Abstract: Cancer-linked mutations A large-scale genetic analysis of more than 400 breast, lung, ovarian and prostate cancer samples has identified thousands of cancer-related mutations. Kan et al. analysed DNA from cancer patients and identified 2,576 somatic mutations across 1,507 coding genes. Of these, 77 are thought to be significantly mutated, implying possible pathogenic roles for protein kinases, G protein-coupled receptors and other potential therapeutic targets.

Date: 2010
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DOI: 10.1038/nature09208

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