Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca2+ channel

Daniela Panáková, Andreas A. Werdich and Calum A. MacRae ()
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Daniela Panáková: Brigham and Women’s Hospital/Harvard Medical School, 75 Francis Street, Thorn 11, Boston, Massachusetts 02115, USA
Andreas A. Werdich: Brigham and Women’s Hospital/Harvard Medical School, 75 Francis Street, Thorn 11, Boston, Massachusetts 02115, USA
Calum A. MacRae: Brigham and Women’s Hospital/Harvard Medical School, 75 Francis Street, Thorn 11, Boston, Massachusetts 02115, USA

Nature, 2010, vol. 466, issue 7308, 874-878

Abstract: Signalling cardiac currents Many important biological processes, including the normal functioning of the heart, require an electrical gradient. The mechanisms that create and maintain such electrical polarities are poorly understood. Using techniques developed to study voltage and calcium in the developing zebrafish heart, Panáková et al. have now identified a previously unrecognized gradient of electrical coupling in the myocardial plane. The emergence of the electrical gradient depends on calcium conductance through the L-type calcium channel, which, surprisingly, is physiologically regulated by Wnt11 signalling. This work shows that electrical patterning of the embryonic heart involves an interaction between an important developmental signal and ion channels in the cell membrane — rather than relying on specialized conduction tissue.

Date: 2010
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DOI: 10.1038/nature09249

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