Amygdalar and hippocampal substrates of anxious temperament differ in their heritability

Jonathan A. Oler, Andrew S. Fox, Steven E. Shelton, Jeffrey Rogers, Thomas D. Dyer, Richard J. Davidson, Wendy Shelledy, Terrence R. Oakes, John Blangero and Ned H. Kalin ()
Additional contact information
Jonathan A. Oler: University of Wisconsin-Madison
Andrew S. Fox: University of Wisconsin-Madison
Steven E. Shelton: University of Wisconsin-Madison
Jeffrey Rogers: Baylor College of Medicine
Thomas D. Dyer: Southwest Foundation for Biomedical Research
Richard J. Davidson: University of Wisconsin-Madison
Wendy Shelledy: Southwest Foundation for Biomedical Research
Terrence R. Oakes: Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison
John Blangero: Southwest Foundation for Biomedical Research
Ned H. Kalin: University of Wisconsin-Madison

Nature, 2010, vol. 466, issue 7308, 864-868

Abstract: Genetic factors in anxiety An anxious temperament in both humans and monkeys is evident from infanthood, is an important risk factor for later psychopathology, and is known to be heritable. In a large-scale study combining imaging with genetics, Oler et al. characterize the neural circuitry associated with this trait and the extent to which the function of this circuit is heritable. They scanned more than 200 related monkeys from a single-family pedigree using positron emission tomography after exposing the monkeys to a mildly stressful situation. Activation in both the amygdala and hippocampus was predictive of anxious temperament, but heritability of hippocampal activity was greater than that for amygdala. This suggests that there may be different effects of genes and environment on the function of these two regions in anxious temperament, and provides new insights into the genetic risk for anxiety and depressive disorders.

Date: 2010
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DOI: 10.1038/nature09282

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