Blocking ubiquitin transfer

April Rose and Christian Schlieker
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April Rose: Yale University, New Haven, Connecticut 06520-8114, USA. christian.schlieker@yale.edu
Christian Schlieker: Yale University, New Haven, Connecticut 06520-8114, USA. christian.schlieker@yale.edu

Nature, 2010, vol. 466, issue 7309, 929-930

Abstract: The protein OTUB1 inhibits DNA repair without using its enzymatic activity. Instead, it sequesters a protein that is required for the assembly of certain forms of ubiquitin chain, which function as key signals during repair.

Date: 2010
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DOI: 10.1038/466929a

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