An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

Matthew P. R. Berry, Christine M. Graham, Finlay W. McNab, Zhaohui Xu, Susannah A. A. Bloch, Tolu Oni, Katalin A. Wilkinson, Romain Banchereau, Jason Skinner, Robert J. Wilkinson, Charles Quinn, Derek Blankenship, Ranju Dhawan, John J. Cush, Asuncion Mejias, Octavio Ramilo, Onn M. Kon, Virginia Pascual, Jacques Banchereau, Damien Chaussabel and Anne O’Garra ()
Additional contact information
Matthew P. R. Berry: MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Christine M. Graham: MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Finlay W. McNab: MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Zhaohui Xu: Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM U899, 3434 Live Oak Street, Dallas, Texas 75204, USA
Susannah A. A. Bloch: St. Mary’s Hospital, Imperial College Healthcare NHS Trust
Tolu Oni: Institute of Infectious Diseases and Molecular Medicine, University of Cape Town
Katalin A. Wilkinson: MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Romain Banchereau: UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
Jason Skinner: Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM U899, 3434 Live Oak Street, Dallas, Texas 75204, USA
Robert J. Wilkinson: MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
Charles Quinn: Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM U899, 3434 Live Oak Street, Dallas, Texas 75204, USA
Derek Blankenship: Institute for Health Care Research and Improvement, Baylor Health Care System
Ranju Dhawan: St Mary’s Hospital, Imperial College Healthcare NHS Trust
John J. Cush: Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM U899, 3434 Live Oak Street, Dallas, Texas 75204, USA
Asuncion Mejias: Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, Ohio 43205, USA
Octavio Ramilo: Center for Vaccines and Immunity, The Research Institute at Nationwide Children’s Hospital, 700 Children’s Drive, Columbus, Ohio 43205, USA
Onn M. Kon: St. Mary’s Hospital, Imperial College Healthcare NHS Trust
Virginia Pascual: Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM U899, 3434 Live Oak Street, Dallas, Texas 75204, USA
Jacques Banchereau: Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM U899, 3434 Live Oak Street, Dallas, Texas 75204, USA
Damien Chaussabel: Baylor Institute for Immunology Research/ANRS Center for Human Vaccines, INSERM U899, 3434 Live Oak Street, Dallas, Texas 75204, USA
Anne O’Garra: MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK

Nature, 2010, vol. 466, issue 7309, 973-977

Abstract: A tuberculosis biomarker The immune response to Mycobacterium tuberculosis is complex and incompletely characterized, hindering the development of new diagnostics, treatments and vaccines. A systems-biology approach has now been used to compare the transcriptional profiles of expressed genes in patients with active and latent tuberculosis and in healthy controls. Active pulmonary disease is shown to correlate with a neutrophil-driven interferon-inducible gene profile. About 10% of people with latent tuberculosis go on to develop the active disease. In this study, 10% of latent patients displayed a transcriptional signature similar to that in the active disease, suggesting that the biomarker may be useful in both prognosis and diagnosis.

Date: 2010
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DOI: 10.1038/nature09247

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