Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells

Paola Bonfanti, Stéphanie Claudinot, Alessandro W. Amici, Alison Farley, C. Clare Blackburn and Yann Barrandon ()
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Paola Bonfanti: Laboratory of Stem Cell Dynamics, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Stéphanie Claudinot: Laboratory of Stem Cell Dynamics, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Alessandro W. Amici: Laboratory of Stem Cell Dynamics, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland
Alison Farley: Institute for Stem Cell Research, MRC Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh
C. Clare Blackburn: Institute for Stem Cell Research, MRC Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh
Yann Barrandon: Laboratory of Stem Cell Dynamics, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland

Nature, 2010, vol. 466, issue 7309, 978-982

Abstract: Thymus cells reprogrammed The thymus serves a variety of functions in the adaptive immune system, including, through the thymic epithelial cells, the production of the self-tolerant thymocytes that develop into T lymphocytes. It has been widely assumed that the thymus contains only progenitor epithelial cells, with a limited repertoire of cell types. But work on rat thymic epithelial cells in cultures shows that, if exposed to the skin microenvironment, they can be reprogrammed to adopt the fate of hair-follicle multipotent stem cells. These cells can be cloned and extensively cultured, properties that are relevant to the possible growth of human thymic epithelial cells and potential clinical applications.

Date: 2010
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DOI: 10.1038/nature09269

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