Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases

Yannick Jacob, Hume Stroud, Chantal LeBlanc, Suhua Feng, Luting Zhuo, Elena Caro, Christiane Hassel, Crisanto Gutierrez, Scott D. Michaels () and Steven E. Jacobsen ()
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Yannick Jacob: Indiana University
Hume Stroud: Cell and Developmental Biology, University of California, Los Angeles
Chantal LeBlanc: Indiana University
Suhua Feng: Howard Hughes Medical Institute, University of California, Los Angeles
Luting Zhuo: Indiana University
Elena Caro: Cell and Developmental Biology, University of California, Los Angeles
Christiane Hassel: Indiana University
Crisanto Gutierrez: Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Nicolas Cabrera 1, Cantoblanco, Madrid 28049, Spain
Scott D. Michaels: Indiana University
Steven E. Jacobsen: Cell and Developmental Biology, University of California, Los Angeles

Nature, 2010, vol. 466, issue 7309, 987-991

Abstract: DNA replication: applying the brakes It is important for the normal function of a cell that DNA replication takes place only once per cell cycle, and various mechanisms exist to prevent its repetition. Another mechanism has been shown to operate in Arabidopsis, this one surprisingly involving two histone (H3K27) monomethyltansferases, ATXR5 and ATXR6. Mutations in the genes encoding these two enzymes lead to re-replication of specific genomic locations, the majority of which correspond to transposons and other repetitive and silenced elements. ATXR5 and ATXR6 are proposed to be components of a pathway required to prevent over-replication of heterochromatin in Arabidopsis.

Date: 2010
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DOI: 10.1038/nature09290

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