Rb regulates fate choice and lineage commitment in vivo

Eliezer Calo, Jose A. Quintero-Estades, Paul S. Danielian, Simona Nedelcu, Seth D. Berman and Jacqueline A. Lees ()
Additional contact information
Eliezer Calo: David H. Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology
Jose A. Quintero-Estades: David H. Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology
Paul S. Danielian: David H. Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology
Simona Nedelcu: David H. Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology
Seth D. Berman: David H. Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology
Jacqueline A. Lees: David H. Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology

Nature, 2010, vol. 466, issue 7310, 1110-1114

Abstract: Rb suppressor and cell fate The tumour suppressor Rb (retinoblastoma protein) is mutated in about one-third of human tumours. It suppresses the activity of certain transcription factors and potentiates the activity of others, and has been shown to affect the differentiation of different cell lineages in vitro. Jacqueline Lees and colleagues now show that Rb plays a role in determining fate choice between bone cell and brown adipose tissue formation in vivo in mouse osteosarcoma models, acting via the bone and fat master regulators Runx2 and PPARγ

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature09264 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:466:y:2010:i:7310:d:10.1038_nature09264

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09264

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().