Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Shinsuke Ito, Ana C. D’Alessio, Olena V. Taranova, Kwonho Hong, Lawrence C. Sowers and Yi Zhang ()
Additional contact information
Shinsuke Ito: Howard Hughes Medical Institute,
Ana C. D’Alessio: Howard Hughes Medical Institute,
Olena V. Taranova: Howard Hughes Medical Institute,
Kwonho Hong: Howard Hughes Medical Institute,
Lawrence C. Sowers: Loma Linda University School of Medicine
Yi Zhang: Howard Hughes Medical Institute,

Nature, 2010, vol. 466, issue 7310, 1129-1133

Abstract: Tet proteins and DNA demethylation The enzymes responsible for methylating DNA, a ubiquitous epigenetic modification, have been extensively studied. Less is known about demethylation. Here, Tet1, an enzyme that catalyses the conversion of 5-methylcytosine of DNA to 5-hydroxyl-methylcytosine, is shown to have a role in mouse embryonic stem-cell maintenance by maintaining the expression of Nanog and preserving the Nanog promoter in a hypomethylated state. This suggests that Tet1 has a role in regulating DNA methylation, as well as in embryonic stem-cell self-renewal and inner cell mass specification.

Date: 2010
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DOI: 10.1038/nature09303

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