OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma

Pedro P. Medina, Mona Nolde and Frank J. Slack ()
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Pedro P. Medina: Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, Connecticut 06520, USA
Mona Nolde: Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, Connecticut 06520, USA
Frank J. Slack: Cellular and Developmental Biology, Yale University, PO Box 208103, New Haven, Connecticut 06520, USA

Nature, 2010, vol. 467, issue 7311, 86-90

Abstract: Tumour addicted to oncomiR MicroRNAs (miRNAs) — small RNA molecules that regulate gene expression and have an important role in establishing cell identity — have been linked to human cancers, where they are referred to as oncomiRs. One model of cancer development proposes that proliferating cells become 'addicted' to activating mutations in an oncogene, and it has been suggested that tumours may also become dependent on oncomiRs. Work in mice that were engineered to conditionally express microRNA-21 (miR-21), which is overexpressed in most tumour types so far analysed, now shows that miR-21 induces pre-B-cell lymphoma. In the absence of miR-21, malignant cells undergo apoptosis and regress, as would be expected if they were addicted to its presence. The pharmacological inactivation of 'oncomiR-21' and other similar miRNAs may therefore be of therapeutic benefit.

Date: 2010
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DOI: 10.1038/nature09284

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