Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

Hengyao Niu, Woo-Hyun Chung, Zhu Zhu, Youngho Kwon, Weixing Zhao, Peter Chi, Rohit Prakash, Changhyun Seong, Dongqing Liu, Lucy Lu, Grzegorz Ira () and Patrick Sung ()
Additional contact information
Hengyao Niu: Yale University School of Medicine
Woo-Hyun Chung: Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Zhu Zhu: Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Youngho Kwon: Yale University School of Medicine
Weixing Zhao: Yale University School of Medicine
Peter Chi: Yale University School of Medicine
Rohit Prakash: Yale University School of Medicine
Changhyun Seong: Yale University School of Medicine
Dongqing Liu: Yale University School of Medicine
Lucy Lu: Yale University School of Medicine
Grzegorz Ira: Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Patrick Sung: Yale University School of Medicine

Nature, 2010, vol. 467, issue 7311, 108-111

Abstract: Priming DNA for repair When DNA damage introduces double-strand breaks, the ends formed must undergo processing to prepare them for repair. In related studies by the Sung and Kowalczykowski laboratories, this processing reaction has been replicated in vitro using yeast proteins. Processing minimally requires the activities of a helicase, a nuclease and a single-strand binding protein, although the reaction is enhanced by further addition of three factors that help target the core complex and enhance the unwinding activity.

Date: 2010
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DOI: 10.1038/nature09318

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