Genome-wide measurement of RNA secondary structure in yeast

Michael Kertesz, Yue Wan, Elad Mazor, John L. Rinn, Robert C. Nutter, Howard Y. Chang () and Eran Segal ()
Additional contact information
Michael Kertesz: Weizmann Institute of Science
Yue Wan: Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine
Elad Mazor: Weizmann Institute of Science
John L. Rinn: The Broad Institute of Harvard and Massachusetts Institute of Technology
Robert C. Nutter: Life Technologies
Howard Y. Chang: Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine
Eran Segal: Weizmann Institute of Science

Nature, 2010, vol. 467, issue 7311, 103-107

Abstract: RNA in close-up Despite the importance of RNA structure for its regulation and function, relatively few RNA structures are known experimentally and there is no experimental method for high-throughput measurement of RNA structure. Instead, computational methods are the norm for genome-wide applications. Recent technologies have allowed RNA structure to be calculated on a larger scale, however. Kertesz et al. use a deep-sequencing approach to determine the structure of the entire transcriptome of the yeast Saccharomyces cerevisiae. The results provide interesting hints about the role of secondary structure in translation, and set the stage for examination of how such structures can change in response to environmental conditions.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.nature.com/articles/nature09322 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:467:y:2010:i:7311:d:10.1038_nature09322

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09322

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().