A spindle-independent cleavage furrow positioning pathway

Clemens Cabernard, Kenneth E. Prehoda and Chris Q. Doe ()
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Clemens Cabernard: Howard Hughes Medical Institute, University of Oregon
Kenneth E. Prehoda: Institute of Molecular Biology, University of Oregon
Chris Q. Doe: Howard Hughes Medical Institute, University of Oregon

Nature, 2010, vol. 467, issue 7311, 91-94

Abstract: Where cells divide In the textbook model of metazoan cell division — based on a century of work on relatively large marine cells and Caenorhabditis elegans — the mitotic spindle is assumed to direct the position of the cleavage furrow. Now experiments to test whether this model is sufficient to explain furrow position during asymmetric cell division of a smaller cell — the Drosophila neuroblast — suggest that it cannot. Instead, a novel pathway operates in which the Pins (Partner of Inscuteable) polarity complex polarizes furrow-forming proteins to the basal cortex where they induce contractile ring formation. This spindle-independent cytokinetic furrow mechanism may be relevant to other highly polarized cell types.

Date: 2010
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DOI: 10.1038/nature09334

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