DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

Petr Cejka, Elda Cannavo, Piotr Polaczek, Taro Masuda-Sasa, Subhash Pokharel, Judith L. Campbell and Stephen C. Kowalczykowski ()
Additional contact information
Petr Cejka: University of California, Davis, Davis, California 95616-8665, USA
Elda Cannavo: University of California, Davis, Davis, California 95616-8665, USA
Piotr Polaczek: California Institute of Technology
Taro Masuda-Sasa: California Institute of Technology
Subhash Pokharel: California Institute of Technology
Judith L. Campbell: California Institute of Technology
Stephen C. Kowalczykowski: University of California, Davis, Davis, California 95616-8665, USA

Nature, 2010, vol. 467, issue 7311, 112-116

Abstract: Priming DNA for repair When DNA damage introduces double-strand breaks, the ends formed must undergo processing to prepare them for repair. In related studies by the Sung and Kowalczykowski laboratories, this processing reaction has been replicated in vitro using yeast proteins. Processing minimally requires the activities of a helicase, a nuclease and a single-strand binding protein, although the reaction is enhanced by further addition of three factors that help target the core complex and enhance the unwinding activity.

Date: 2010
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/nature09355 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:467:y:2010:i:7311:d:10.1038_nature09355

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09355

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().