Production of p53 gene knockout rats by homologous recombination in embryonic stem cells

Chang Tong, Ping Li, Nancy L. Wu, Youzhen Yan and Qi-Long Ying ()
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Chang Tong: Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California
Ping Li: Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California
Nancy L. Wu: USC/Norris Cancer Center Transgenic/Knockout Core Facility, Keck School of Medicine, University of Southern California
Youzhen Yan: USC/Norris Cancer Center Transgenic/Knockout Core Facility, Keck School of Medicine, University of Southern California
Qi-Long Ying: Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California

Nature, 2010, vol. 467, issue 7312, 211-213

Abstract: On target for p53 knockout in the rat The rat is a widely used animal model for studying human physiology and disease, but functional genomics and genetic research have been stifled by the limited availability of gene-targeting tools. Qi-Long Ying and colleagues have now established gene targeting by homologous recombination in rat embryonic stem cells, and have generated for the first time p53 gene-knockout rats, suitable for physiological and pharmacological studies of the ubiquitous tumour suppressor p53.

Date: 2010
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DOI: 10.1038/nature09368

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