Graphene as a subnanometre trans-electrode membrane

S. Garaj (), W. Hubbard, A. Reina, J. Kong, D. Branton and J. A. Golovchenko ()
Additional contact information
S. Garaj: Harvard University
W. Hubbard: School of Engineering and Applied Sciences, Harvard University
A. Reina: Massachusetts Institute of Technology
J. Kong: Massachusetts Institute of Technology
D. Branton: Harvard University
J. A. Golovchenko: Harvard University

Nature, 2010, vol. 467, issue 7312, 190-193

Abstract: DNA sequencing: enter the graphene nanopore Atomically thin layers of graphite — known as graphene — are highly electronically conducting across the plane of the material. Now researchers from Harvard University and the Massachusetts Institute of Technology show that, when used as a membrane separating two liquid reservoirs, graphene is strongly ionically insulating, while its in-plane electronic properties are strongly dependent on the inter-facial environment. The membrane prevents ions and water from flowing through it, but can attract various ions and other molecules to its two atomically close surfaces. A variety of analytical applications may result. For instance, the authors show that by drilling pores a few nanometres in diameter into these 'trans-electrode' membranes, it is possible to thread a long DNA molecule through the graphene nanopore. The DNA blocks the flow of ions, resulting in a characteristic electrical signal reflecting the size and conformation of the molecule. Such a system has potential as the basis of devices that could significantly reduce the cost of DNA sequencing.

Date: 2010
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DOI: 10.1038/nature09379

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