Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal

Adan Aguirre, Maria E. Rubio and Vittorio Gallo ()
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Adan Aguirre: Center for Neuroscience Research, Children’s National Medical Center
Maria E. Rubio: University of Pittsburgh Medical School
Vittorio Gallo: Center for Neuroscience Research, Children’s National Medical Center

Nature, 2010, vol. 467, issue 7313, 323-327

Abstract: Neural stem cells in balance The subventricular zone (SVZ) of the adult mammalian brain is an important site for cell proliferation, contributing to nerve-cell self-renewal and the response to injury. The SVZ stem-cell niche maintains neural stem cells (NSCs) and neural progenitor cells (NPCs), with the balance between the two being vital to normal brain development. Notch signalling is known to regulate NSC self-renewal, whereas EGFR (epidermal growth factor receptor) signalling affects NPC proliferation. Aguirre et al. show that these pathways interact to maintain a balance between NSC and NPC populations through EGFR-mediated regulation of Notch signalling. This points to specific signalling pathways that may be targeted to enhance production of NSCs or NPCs after injury.

Date: 2010
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DOI: 10.1038/nature09347

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