Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo

Michael R. Elliott, Shuqiu Zheng, Daeho Park, Robin I. Woodson, Michael A. Reardon, Ignacio J. Juncadella, Jason M. Kinchen, Jun Zhang, Jeffrey J. Lysiak () and Kodi S. Ravichandran ()
Additional contact information
Michael R. Elliott: Beirne B. Carter Center for Immunology Research, University of Virginia
Shuqiu Zheng: University of Virginia
Daeho Park: Beirne B. Carter Center for Immunology Research, University of Virginia
Robin I. Woodson: University of Virginia
Michael A. Reardon: University of Virginia
Ignacio J. Juncadella: Beirne B. Carter Center for Immunology Research, University of Virginia
Jason M. Kinchen: Center for Cell Clearance, University of Virginia
Jun Zhang: University of Virginia
Jeffrey J. Lysiak: Center for Cell Clearance, University of Virginia
Kodi S. Ravichandran: Beirne B. Carter Center for Immunology Research, University of Virginia

Nature, 2010, vol. 467, issue 7313, 333-337

Abstract: Clearance of apoptotic germ cells by ELMO1 Apoptotic cell death is crucial for tissue development and function and occurs throughout mammalian life. Removal of dying cells by phagocytes is important to prevent tissue dysfunction, but the mechanisms that regulate clearance of dying cells in vivo remain unclear. In this study, Elliott et al. reveal a crucial role for a conserved engulfment protein, ELMO1, in the phagocytic clearance of apoptotic germ cells by Sertoli cells and the maintenance of normal testicular homeostasis.

Date: 2010
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DOI: 10.1038/nature09356

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