Comprehensive methylome map of lineage commitment from haematopoietic progenitors

Hong Ji, Lauren I. R. Ehrlich, Jun Seita, Peter Murakami, Akiko Doi, Paul Lindau, Hwajin Lee, Martin J. Aryee, Rafael A. Irizarry, Kitai Kim, Derrick J. Rossi, Matthew A. Inlay, Thomas Serwold, Holger Karsunky, Lena Ho, George Q. Daley, Irving L. Weissman and Andrew P. Feinberg ()
Additional contact information
Hong Ji: Johns Hopkins University School of Medicine, 570 Rangos, 725 N. Wolfe St., Baltimore, Maryland 21205, USA
Lauren I. R. Ehrlich: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Jun Seita: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Peter Murakami: Johns Hopkins University School of Medicine, 570 Rangos, 725 N. Wolfe St., Baltimore, Maryland 21205, USA
Akiko Doi: Johns Hopkins University School of Medicine, 570 Rangos, 725 N. Wolfe St., Baltimore, Maryland 21205, USA
Paul Lindau: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Hwajin Lee: Johns Hopkins University School of Medicine, 570 Rangos, 725 N. Wolfe St., Baltimore, Maryland 21205, USA
Martin J. Aryee: Johns Hopkins Bloomberg School of Public Health
Rafael A. Irizarry: Johns Hopkins University School of Medicine, 570 Rangos, 725 N. Wolfe St., Baltimore, Maryland 21205, USA
Kitai Kim: Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Harvard Medical School; Harvard Stem Cell Institute
Derrick J. Rossi: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Matthew A. Inlay: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Thomas Serwold: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Holger Karsunky: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Lena Ho: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
George Q. Daley: Stem Cell Transplantation Program, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Harvard Medical School; Harvard Stem Cell Institute
Irving L. Weissman: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Andrew P. Feinberg: Johns Hopkins University School of Medicine, 570 Rangos, 725 N. Wolfe St., Baltimore, Maryland 21205, USA

Nature, 2010, vol. 467, issue 7313, 338-342

Abstract: Stem cells with baggage Induced pluripotent stem (iPS) cells are produced by reprogramming differentiated adult cells using a cocktail of transcription factors. They share many properties that are characteristic of embryonic stem (ES) cells generated by somatic-cell nuclear transfer (SCNT), and of ES cells from naturally fertilized embryos. The three cell types are not identical, however, and an interesting difference has now been discovered: iPS cells retain an 'epigenetic memory' of the donor tissue from which they derive, whereas SCNT-based reprogramming resets the DNA-methylation state of adult cells so it is closer to the ES cell-like state. In a separate study, Ji et al. examine the role of specific DNA methylation marks in the developmental progression of particular cell lineages. They present a genome-wide DNA-methylation analysis of haematopoietic cell populations that reveals remarkable epigenetic plasticity. Changes in DNA methylation emerge as perhaps a principal factor directing cell-fate choices such as commitment to myeloid or lymphoid development.

Date: 2010
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DOI: 10.1038/nature09367

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