Oligomeric organization of the B-cell antigen receptor on resting cells

Jianying Yang and Michael Reth ()
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Jianying Yang: Centre for Biological Signalling Studies BIOSS, Albert-Ludwigs-Universität Freiburg, Faculty of Biology, Albert-Ludwigs-Universität Freiburg and Max Planck Institute for Immunobiology, Stübeweg 51, 79108 Freiburg, Germany
Michael Reth: Centre for Biological Signalling Studies BIOSS, Albert-Ludwigs-Universität Freiburg, Faculty of Biology, Albert-Ludwigs-Universität Freiburg and Max Planck Institute for Immunobiology, Stübeweg 51, 79108 Freiburg, Germany

Nature, 2010, vol. 467, issue 7314, 465-469

Abstract: B cells at rest A B lymphocyte has the potential to respond to a vast number of antigens thanks to the 120,000 or so B-cell antigen receptor (BCR) complexes on its cell surface. Much work has been done on the nature of the BCR activation process. Here, Jianying Yang and Michael Reth look at the status of the BCR before activation. Their data support a model in which most BCR complexes on resting B cells reside in closed (autoinhibited) oligomers. The authors propose that it is the opening of closed BCR oligomers — rather than the cross-linking of monomers — that drives B cell activation.

Date: 2010
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DOI: 10.1038/nature09357

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