Ptychographic X-ray computed tomography at the nanoscale

Martin Dierolf, Andreas Menzel, Pierre Thibault (), Philipp Schneider, Cameron M. Kewish, Roger Wepf, Oliver Bunk and Franz Pfeiffer
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Martin Dierolf: Technische Universität München
Andreas Menzel: Swiss Light Source, Paul Scherrer Institut
Pierre Thibault: Technische Universität München
Philipp Schneider: Institute for Biomechanics, ETH Zurich, 8093 Zurich, Switzerland
Cameron M. Kewish: Swiss Light Source, Paul Scherrer Institut
Roger Wepf: Electron Microscopy ETH Zurich (EMEZ)
Oliver Bunk: Swiss Light Source, Paul Scherrer Institut
Franz Pfeiffer: Technische Universität München

Nature, 2010, vol. 467, issue 7314, 436-439

Abstract: Nanoscale computed tomography Established X-ray tomography techniques can reveal the three-dimensional internal structure of entire organisms and of single cells, as well as quantitative information, usually calculated from X-ray attenuation data. A newly emerging X-ray computed tomography technique that uses 'ptychographic' X-ray imaging — which can extract detailed phase contrast information from even weakly absorbing objects — is now taking quantitative X-ray imaging into the nanoworld. Sensitive to density variations of less than 1%, the potential of the new method is demonstrated by producing three-dimensional images of a bone specimen in which structures on the 100-nanometre scale, such as the osteocyte lacunae and the interconnective canalicular network, are clearly resolved. High-resolution quantitative tomography of this type may find applications in biomedicine and in microanalysis of fossils as well as in materials science.

Date: 2010
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DOI: 10.1038/nature09419

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