Selectivity mechanism of the nuclear pore complex characterized by single cargo tracking

Alan R. Lowe, Jake J. Siegel, Petr Kalab, Merek Siu, Karsten Weis () and Jan T. Liphardt
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Alan R. Lowe: University of California
Jake J. Siegel: QB3, University of California
Petr Kalab: University of California
Merek Siu: Biophysics Graduate Group, University of California
Karsten Weis: QB3, University of California
Jan T. Liphardt: University of California

Nature, 2010, vol. 467, issue 7315, 600-603

Abstract: Nuclear pore complex selectivity Nuclear pore complexes selectively transport cargoes across the nuclear envelope. Now, two studies published in this issue follow the movement of single cargo proteins (Lowe et al.) and mRNA transcripts (David Grünwald and Robert Singer) as they translocate across the nuclear envelope, with nanometre precision and high temporal resolution. They discover previously unidentified transport sub-steps and provide fundamental insight into the mechanism of selective transport through the nuclear pore complexes.

Date: 2010
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DOI: 10.1038/nature09285

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