Identification of a quality-control mechanism for mRNA 5′-end capping

Xinfu Jiao, Song Xiang, ChanSeok Oh, Charles E. Martin, Liang Tong and Megerditch Kiledjian ()
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Xinfu Jiao: Rutgers University
Song Xiang: Columbia University
ChanSeok Oh: Rutgers University
Charles E. Martin: Rutgers University
Liang Tong: Columbia University
Megerditch Kiledjian: Rutgers University

Nature, 2010, vol. 467, issue 7315, 608-611

Abstract: Quality control for mRNA Following their transcription, eukaryotic messenger RNAs have a 7-methylguanosine cap added to their 5′ ends to protect the mRNA from degradation. Xinfu Jiao et al. show that caps lacking a methyl group are recognized by Rai1, which clips off the incomplete cap. These data suggest that Rai1 is part of a quality-control mechanism that monitors and promotes the digestion of aberrant mRNAs that may arise during stress conditions.

Date: 2010
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DOI: 10.1038/nature09338

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