Translating cancer research into targeted therapeutics

J. S. de Bono () and Alan Ashworth ()
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J. S. de Bono: The Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
Alan Ashworth: The Breakthrough Breast Cancer Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK

Nature, 2010, vol. 467, issue 7315, 543-549

Abstract: The route to targeted anticancer drugs In a Perspectives review, Johann de Bono and Alan Ashworth take a critical look at current procedures for clinical trials in cancer. The emphasis of anticancer drug development is now firmly on molecularly targeted, rationally designed agents rather than nonspecific cytotoxins. Yet despite some successes, the prognosis for many cancers — such as pancreatic and lung cancer — remains poor. Many trials have little effect on either patient outcome or our understanding of cancer biology, arriving instead at a best treatment for the average patient rather than for any individual. De Bono and Ashworth argue for a new approach involving integrated cancer research and biomarker-driven adaptive and hypothesis testing clinical trials. The potential of structure-guided drug discovery in treating cancer is demonstrated elsewhere in this issue in a paper on the B-RAF inhibitor PLX4032; see, http://go.nature.com/QnVGQx ).

Date: 2010
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DOI: 10.1038/nature09339

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