Genome-wide analysis of a long-term evolution experiment with Drosophila

Molly K. Burke (), Joseph P. Dunham, Parvin Shahrestani, Kevin R. Thornton, Michael R. Rose and Anthony D. Long ()
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Molly K. Burke: Ecology and Evolutionary Biology, University of California, Irvine, 321 Steinhaus Hall, Irvine, California 92697-2525, USA
Joseph P. Dunham: Molecular and Computational Biology, University of Southern California
Parvin Shahrestani: Ecology and Evolutionary Biology, University of California, Irvine, 321 Steinhaus Hall, Irvine, California 92697-2525, USA
Kevin R. Thornton: Ecology and Evolutionary Biology, University of California, Irvine, 321 Steinhaus Hall, Irvine, California 92697-2525, USA
Michael R. Rose: Ecology and Evolutionary Biology, University of California, Irvine, 321 Steinhaus Hall, Irvine, California 92697-2525, USA
Anthony D. Long: Ecology and Evolutionary Biology, University of California, Irvine, 321 Steinhaus Hall, Irvine, California 92697-2525, USA

Nature, 2010, vol. 467, issue 7315, 587-590

Abstract: Experimental evolution reveals resistance to change Until now, experimental evolution has been largely performed in asexual systems with small genomes, such as bacteria and yeast. Burke et al. report results of a genome-wide study in Drosophila melanogaster fruitfly populations, which were selected in the lab for more than 600 generations to develop rapidly from egg to adult. In contrast to what is seen in asexual populations, the authors report 'soft' selective sweeps in which selection acts on pre-existing, common genetic variants, and conclude that unconditionally advantageous alleles rarely arise, are associated with small net fitness gains, or cannot fix because selection coefficients change over time.

Date: 2010
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DOI: 10.1038/nature09352

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