Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation

Tatsuya Tsukahara, Yuji Tanno and Yoshinori Watanabe ()
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Tatsuya Tsukahara: Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113-0032, Japan
Yuji Tanno: Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113-0032, Japan
Yoshinori Watanabe: Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Tokyo 113-0032, Japan

Nature, 2010, vol. 467, issue 7316, 719-723

Abstract: Chromosome bi-orientation The chromosomal passenger complex (CPC) coordinates several processes during cell division, including chromosome bi-orientation and cytokinesis, and proper localization of this complex is crucial for its diverse functions. In this study, Yoshinori Watanabe and colleagues provide a mechanism for the localization of the CPC to the inner centromere. Cdk1–cyclin-B-dependent phosphorylation of the CPC promotes binding to shugoshin, which the authors now define as a conserved centromeric adaptor of the CPC. This mechanism is conserved between fission yeast and human cells and highlights a crucial role of Cdk1–cyclin B in chromosome bi-orientation.

Date: 2010
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DOI: 10.1038/nature09390

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