Structure of a fucose transporter in an outward-open conformation

Shangyu Dang, Linfeng Sun, Yongjian Huang, Feiran Lu, Yufeng Liu, Haipeng Gong, Jiawei Wang () and Nieng Yan ()
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Shangyu Dang: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Linfeng Sun: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Yongjian Huang: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Feiran Lu: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Yufeng Liu: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Haipeng Gong: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Jiawei Wang: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
Nieng Yan: State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University

Nature, 2010, vol. 467, issue 7316, 734-738

Abstract: FucP: an open and shut case MFS (major facilitator superfamily) transporters are an ancient and ubiquitous class of transport protein. After several decades of research, the structures of three MFS transporters were known — LacY and GlpT in an inward-open conformation and EmrD in an intermediate conformation. The lack of a known structure for an MFS transporter in the outward-open conformation has limited the mechanistic understanding of their function. That gap has now been filled with the publication of the structure of FucP, the Escherichia coli transporter responsible for the uptake of L-fucose, an important source of carbon for microorganisms, in the outward-open conformation.

Date: 2010
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DOI: 10.1038/nature09406

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