The ploidy conveyor of mature hepatocytes as a source of genetic variation

Andrew W. Duncan, Matthew H. Taylor, Raymond D. Hickey, Amy E. Hanlon Newell, Michelle L. Lenzi, Susan B. Olson, Milton J. Finegold and Markus Grompe
Additional contact information
Andrew W. Duncan: Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University
Matthew H. Taylor: Oregon Health & Science University
Raymond D. Hickey: Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University
Amy E. Hanlon Newell: Oregon Health & Science University
Michelle L. Lenzi: Oregon Health & Science University
Susan B. Olson: Oregon Health & Science University
Milton J. Finegold: Texas Children’s Hospital, Houston, Texas 77030, USA
Markus Grompe: Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health & Science University

Nature, 2010, vol. 467, issue 7316, 707-710

Abstract: Polyploidy in liver cells Many liver cells are polyploid, containing 4, 8, 16 or more times the haploid chromosome complement, although the significance of the phenomenon is not known. A study in mice now shows that hepatocytes can both increase and decrease their ploidy in vivo. Ploidy reversal was previously thought to be exclusive to meiosis, but this work shows that it can also occur in normal somatic cells. Increases in ploidy occur through failed cytokinesis, and decreases as a result of multipolar mitosis. The resulting genetic heterogeneity might be advantageous following hepatic injury when 'genetically robust' cells could be selected from a pre-existing pool of diverse genotypes.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature09414 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:467:y:2010:i:7316:d:10.1038_nature09414

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09414

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().