Asterless is a scaffold for the onset of centriole assembly

Nikola S. Dzhindzhev (), Quan D. Yu, Kipp Weiskopf, George Tzolovsky, Ines Cunha-Ferreira, Maria Riparbelli, Ana Rodrigues-Martins, Monica Bettencourt-Dias, Giuliano Callaini and David M. Glover ()
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Nikola S. Dzhindzhev: Cancer Research UK Cell Cycle Genetics Group, University of Cambridge
Quan D. Yu: Cancer Research UK Cell Cycle Genetics Group, University of Cambridge
Kipp Weiskopf: Cancer Research UK Cell Cycle Genetics Group, University of Cambridge
George Tzolovsky: Cancer Research UK Cell Cycle Genetics Group, University of Cambridge
Ines Cunha-Ferreira: Cancer Research UK Cell Cycle Genetics Group, University of Cambridge
Maria Riparbelli: Università di Siena, via Aldo Moro, 2-53100 Siena, Italy
Ana Rodrigues-Martins: Cancer Research UK Cell Cycle Genetics Group, University of Cambridge
Monica Bettencourt-Dias: Instituto Gulbenkian de Ciencia
Giuliano Callaini: Università di Siena, via Aldo Moro, 2-53100 Siena, Italy
David M. Glover: Cancer Research UK Cell Cycle Genetics Group, University of Cambridge

Nature, 2010, vol. 467, issue 7316, 714-718

Abstract: On the scaffold Centrioles, cellular organelles composed of cylindrical arrays of nine microtubules, are essential for the formation of cilia, flagella and the centrosomes that organize microtubule structures within animal cells. Abnormal regulation of centriole duplication can lead to cancers and a number of ciliary diseases, and the centriolar protein Plk4 (Polo-like-kinase 4) is known to be a key regulator of centriole assembly. Now, David Glover and colleagues identify a single centriolar component, Asterless, as a scaffold for the binding of both Plk4 and another protein essential for centriole formation, Sas-4, with a key role in promoting centriole duplication.

Date: 2010
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DOI: 10.1038/nature09445

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