Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

Faraaz B. Chekeni, Michael R. Elliott, Joanna K. Sandilos, Scott F. Walk, Jason M. Kinchen, Eduardo R. Lazarowski, Allison J. Armstrong, Silvia Penuela, Dale W. Laird, Guy S. Salvesen, Brant E. Isakson, Douglas A. Bayliss and Kodi S. Ravichandran ()
Additional contact information
Faraaz B. Chekeni: Beirne B. Carter Center for Immunology Research,
Michael R. Elliott: Beirne B. Carter Center for Immunology Research,
Joanna K. Sandilos: University of Virginia, Charlottesville, Virginia 22908, USA
Scott F. Walk: Beirne B. Carter Center for Immunology Research,
Jason M. Kinchen: Beirne B. Carter Center for Immunology Research,
Eduardo R. Lazarowski: University of North Carolina
Allison J. Armstrong: Beirne B. Carter Center for Immunology Research,
Silvia Penuela: University of Western Ontario
Dale W. Laird: University of Western Ontario
Guy S. Salvesen: Program in Apoptosis and Cell Death Research, The Burnham Institute for Medical Research
Brant E. Isakson: University of Virginia
Douglas A. Bayliss: University of Virginia, Charlottesville, Virginia 22908, USA
Kodi S. Ravichandran: Beirne B. Carter Center for Immunology Research,

Nature, 2010, vol. 467, issue 7317, 863-867

Abstract: Pannexin 1 helps attract phagocytes Apoptotic cells were shown recently to discharge the nucleotides ATP and UTP to act as 'find-me' signals for phagocytes that engulf dying cells before they release potentially harmful cellular contents. This paper shows that the release of ATP and UTP is through the plasma membrane channel pannexin 1, which is specifically opened by caspase activity. The discovery of a role for pannexin 1 in phagocyte chemoattraction could have implications for human diseases that arise from defective clearance of dying cells.

Date: 2010
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DOI: 10.1038/nature09413

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