Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1

Jun Arii, Hideo Goto, Tadahiro Suenaga, Masaaki Oyama, Hiroko Kozuka-Hata, Takahiko Imai, Atsuko Minowa, Hiroomi Akashi, Hisashi Arase, Yoshihiro Kawaoka and Yasushi Kawaguchi ()
Additional contact information
Jun Arii: International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
Hideo Goto: The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
Tadahiro Suenaga: Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan
Masaaki Oyama: Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
Hiroko Kozuka-Hata: Medical Proteomics Laboratory, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
Takahiko Imai: International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
Atsuko Minowa: International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
Hiroomi Akashi: Graduate School of Agricultural and Life Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan
Hisashi Arase: Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan
Yoshihiro Kawaoka: The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
Yasushi Kawaguchi: International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan

Nature, 2010, vol. 467, issue 7317, 859-862

Abstract: A herpes simplex virus-1 entry protein The entry of herpes simplex virus-1 (HSV-1) into cells requires the presence of cellular receptors for both envelope glycoproteins B and D. Now a proteomics-based search for further molecules interacting with HSV-1 has identified non-muscle myosin heavy chain IIA (NMHC-IIA) as a functional entry receptor, acting together with glycoprotein D. NMHC-IIA knockdown reduces HSV-1 infection in cell culture and a mouse model, suggesting that drugs or vaccines that target NMHC-IIA and non-muscle myosin IIA regulators may be effective against herpes infections.

Date: 2010
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DOI: 10.1038/nature09420

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