Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

Xiaoxia Z. West, Nikolay L. Malinin, Alona A. Merkulova, Mira Tischenko, Bethany A. Kerr, Ernest C. Borden, Eugene A. Podrez, Robert G. Salomon and Tatiana V. Byzova ()
Additional contact information
Xiaoxia Z. West: J. J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation
Nikolay L. Malinin: J. J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation
Alona A. Merkulova: J. J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation
Mira Tischenko: J. J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation
Bethany A. Kerr: J. J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation
Ernest C. Borden: Taussig Cancer Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
Eugene A. Podrez: J. J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation
Robert G. Salomon: Case Western Reserve University
Tatiana V. Byzova: J. J. Jacobs Center for Thrombosis and Vascular Biology, NB50, The Cleveland Clinic Foundation

Nature, 2010, vol. 467, issue 7318, 972-976

Abstract: TLR2 links immunity, oxidation and angiogenesis Inflammation is known to cause oxidative stress and the growth of new blood vessels, and now a molecular mechanism linking these processes has been found. Oxidized products of lipid oxidation — (carboxy alkyl)pyrrole protein adducts — are generated during inflammation and wound healing. These products are shown to act as endogenous agonists for Toll-like receptor 2 (TLR2), which stimulates blood vessel growth through a mechanism that is independent of vascular endothelial growth factor. This work establishes a new function for TLR2 as a sensor of oxidation-associated molecular patterns, providing a link connecting inflammation, oxidative stress, innate immunity and angiogenesis.

Date: 2010
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DOI: 10.1038/nature09421

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